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[热角膜移植术]

[Keratoplasty à chaud].

作者信息

Stübiger N, Pleyer U, Erb C, Thiel H J

机构信息

Universitäts-Augenklinik Tübingen.

出版信息

Ophthalmologe. 1995 Aug;92(4):427-32.

PMID:7549324
Abstract

Between 1980 and 1992 we performed 128 keratoplasties à chaud on 69 (54%) eyes with progressive bacterial and on 59 (46%) eyes with progressive herpetic keratitis. In 44 of the eyes the corneas were spontaneously perforated, and in 28 (22%) a descemetocele was present. Only grafts that had been followed for at least 1 year (3.2 +/- 2.4 years) were analyzed. During this time 88 (95%) of the severely threatened eyes were preserved. In the operated eyes visual acuity improved in 20 (54%) in the bacterial and in 36 (69%) in the herpetic group. The main complications were immunological allograft rejection, cataract progression and recurrence of herpes. Allograft rejection occurred in 29 (71%) of the bacterial grafts and remained irreversible in 18 (44%) cases. 30 (63%) eyes in the group with herpetic corneal lesions developed graft rejection, 19 (37%) of these rejections were irreversible. Cataract occurred in the postoperative course in 25 (61%) of the bacterial eyes and in 23 (44%) of the herpetic ones. Recurrence of herpes presented a specific problem in this group and appeared in 12 (23%) of the grafts during a follow-up of 1 month to 12 years (3.8 +/- 2.4 years). Our results demonstrate that keratoplasty à chaud is a valuable form of managing urgent pathological processes of the cornea and shortening the course of the disease. This procedure also allows satisfactory primary functional results in many cases, however, secondary re-keratoplasty and cataract surgery are necessary to achieve functional rehabilitation.

摘要

1980年至1992年间,我们对69只(54%)患有进行性细菌性角膜炎的眼睛和59只(46%)患有进行性疱疹性角膜炎的眼睛进行了128次热角膜移植术。44只眼睛的角膜自发穿孔,28只(22%)存在后弹力层膨出。仅对随访至少1年(3.2±2.4年)的移植片进行分析。在此期间,88只(95%)受到严重威胁的眼睛得以保留。在手术治疗的眼睛中,细菌性角膜炎组20只(54%)视力提高,疱疹性角膜炎组36只(69%)视力提高。主要并发症为免疫性同种异体移植排斥反应、白内障进展和疱疹复发。29只(71%)细菌性移植片发生同种异体移植排斥反应,18只(44%)病例中排斥反应仍不可逆。疱疹性角膜病变组30只(63%)眼睛发生移植排斥反应,其中19只(37%)排斥反应不可逆。细菌性角膜炎组25只(61%)眼睛术后发生白内障,疱疹性角膜炎组23只(44%)眼睛发生白内障。疱疹复发是该组的一个特殊问题,在1个月至12年(3.8±2.4年)的随访期间,12只(23%)移植片出现疱疹复发。我们的结果表明,热角膜移植术是处理角膜紧急病理过程和缩短病程的一种有价值的方法。该手术在许多情况下也能取得满意的主要功能结果,然而,为实现功能康复,二次再次角膜移植术和白内障手术是必要的。

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