Sheffield V C, Nishimura D Y, Stone E M
Department of Pediatrics, University of Iowa, Iowa City 52242, USA.
Curr Opin Genet Dev. 1995 Jun;5(3):335-41. doi: 10.1016/0959-437x(95)80048-4.
The recent progress seen in the development of high-quality genetic markers and high-density human genetic maps is facilitating new strategies for mapping disease-causing and disease-susceptibility genes. These strategies, which include homozygosity mapping, DNA pooling, and the utilization of linkage disequilibrium, have been successfully applied to the mapping and fine mapping of several loci causing diseases segregating in genetically isolated populations.
高质量遗传标记和高密度人类遗传图谱开发方面取得的最新进展，正在推动用于绘制致病基因和疾病易感基因图谱的新策略。这些策略包括纯合性图谱绘制、DNA池化以及连锁不平衡的利用，已成功应用于对在遗传隔离群体中分离的几种致病基因座的定位和精细定位。
