Vega-Matuszczyk J, Ahlenius S, Eneroth P, Larsson K
Department of Psychology, University of Göteborg, Sweden.
Eur Neuropsychopharmacol. 1995 Jun;5(2):115-8. doi: 10.1016/0924-977X(95)00008-D.
The present experiments demonstrate that 8-OH-DPAT (0.25 mg/kg SC, - 15 min) produced a decrease in the ejaculatory threshold to the same extent in adrenalectomized male rats as in sham operated controls. Both groups of animals displayed a marked and statistically significant decrease in number of mounts and penile intromissions preceding ejaculation and in the ejaculation latency, as a result of treatment with 8-OH-DPAT. Adrenalectomy per se did not affect any aspect of the male rat's sexual behavior (latency to first intromission, number of mounts or penile intromissions, ejaculation latency or the postejaculatory interval). The surgical removal of the adrenals was verified by measurements of plasma corticosterone levels. It is concluded that well documented effects of 8-OH-DPAT on adrenal secretions do not contribute to its ability to decrease the ejaculatory threshold in male rats.
目前的实验表明，8-羟基二丙胺基四氢吡咯（0.25毫克/千克，皮下注射，-15分钟）使去肾上腺雄性大鼠的射精阈值降低，其程度与假手术对照组相同。两组动物在接受8-羟基二丙胺基四氢吡咯治疗后，射精前的爬跨次数和阴茎插入次数以及射精潜伏期均显著减少，且具有统计学意义。单纯肾上腺切除术并未影响雄性大鼠性行为的任何方面（首次插入潜伏期、爬跨次数或阴茎插入次数、射精潜伏期或射精后间隔）。通过测量血浆皮质酮水平证实了肾上腺的手术切除。结论是，8-羟基二丙胺基四氢吡咯对肾上腺分泌的明确作用与其降低雄性大鼠射精阈值的能力无关。
