Bonne O, Shalev A Y, Bloch M
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel.
Eur Neuropsychopharmacol. 1995 Jun;5(2):147-9. doi: 10.1016/0924-977X(95)00014-G.
Delirium may develop in vulnerable subjects under normal doses of psychotropic drugs. The occurrence of delirium in patients treated with tricyclic antidepressants is attributed to the anticholinergic activity of these drugs. Mianserin, characterized by low anticholinergic activity, has been recommended for treatment of depression in elderly patients. We report five cases of delirium in elderly patients treated with mianserin. The incidence of organo-mental side effects associated with this drug may be higher than previously reported.
在正常剂量的精神药物作用下，易患谵妄的患者可能会出现谵妄。三环类抗抑郁药治疗的患者发生谵妄归因于这些药物的抗胆碱能活性。米安色林具有低抗胆碱能活性的特点，已被推荐用于治疗老年患者的抑郁症。我们报告了5例接受米安色林治疗的老年患者发生谵妄的病例。与这种药物相关的器质性精神副作用的发生率可能比以前报道的要高。
