Appelbaum F R
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Stem Cells. 1995 Jul;13(4):344-50. doi: 10.1002/stem.5530130404.
Three hematopoietic growth factors, recombinant human granulocyte-macrophage colony-stimulating factor, recombinant human granulocyte colony-stimulating factor and erythropoietin, which are commonly used in other clinical situations are being increasingly studied in the setting of allogeneic marrow transplantation. Major questions being addressed are: 1) can administration of growth factors post-transplant accelerate hematopoietic recovery, 2) are growth factors of use in the treatment of patients with poor graft function or graft failure, 3) can growth factor mobilized peripheral blood stem cells be used as a substitute for allogeneic marrow and 4) is there a role for the use of growth factors in the treatment of patients with specific types of infection post-transplant? This review will discuss where we are in answering these four questions.
三种造血生长因子，即重组人粒细胞巨噬细胞集落刺激因子、重组人粒细胞集落刺激因子和促红细胞生成素，在其他临床情况下常用，目前在异基因骨髓移植领域正受到越来越多的研究。正在探讨的主要问题有：1）移植后给予生长因子能否加速造血恢复；2）生长因子对移植功能不良或移植失败的患者治疗是否有用；3）生长因子动员的外周血干细胞能否替代异基因骨髓；4）移植后特定类型感染患者的治疗中生长因子是否发挥作用？本综述将讨论在回答这四个问题方面我们目前所处的阶段。
