Coulie P G
Ludwig Institute for Cancer Research, Brussels Branch, Belgium.
Stem Cells. 1995 Jul;13(4):393-403. doi: 10.1002/stem.5530130410.
It has been known for many years that cytolytic T lymphocytes that specifically recognize the tumor cells of the same patient can be derived from the blood of melanoma patients. Several of the antigens recognized by these antitumor T lymphocytes have now been completely identified. Some of them are sufficiently tumor-specific to envision their use as antitumor vaccines in selected cancer patients.
多年来人们已经知道，能够特异性识别同一患者肿瘤细胞的细胞毒性T淋巴细胞可以从黑色素瘤患者的血液中获得。现在，这些抗肿瘤T淋巴细胞识别的几种抗原已被完全鉴定出来。其中一些抗原具有足够的肿瘤特异性，有望在特定癌症患者中用作抗肿瘤疫苗。
