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细胞毒性T淋巴细胞识别的人类肿瘤抗原:用于疫苗接种?

Antigens recognized on human tumors by cytolytic T lymphocytes: towards vaccination?

作者信息

Coulie P G

机构信息

Ludwig Institute for Cancer Research, Brussels Branch, Belgium.

出版信息

Stem Cells. 1995 Jul;13(4):393-403. doi: 10.1002/stem.5530130410.

Abstract

It has been known for many years that cytolytic T lymphocytes that specifically recognize the tumor cells of the same patient can be derived from the blood of melanoma patients. Several of the antigens recognized by these antitumor T lymphocytes have now been completely identified. Some of them are sufficiently tumor-specific to envision their use as antitumor vaccines in selected cancer patients.

摘要

多年来人们已经知道,能够特异性识别同一患者肿瘤细胞的细胞毒性T淋巴细胞可以从黑色素瘤患者的血液中获得。现在,这些抗肿瘤T淋巴细胞识别的几种抗原已被完全鉴定出来。其中一些抗原具有足够的肿瘤特异性,有望在特定癌症患者中用作抗肿瘤疫苗。

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