Marquis S T, Rajan J V, Wynshaw-Boris A, Xu J, Yin G Y, Abel K J, Weber B L, Chodosh L A
Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104-6069, USA.
Nat Genet. 1995 Sep;11(1):17-26. doi: 10.1038/ng0995-17.
We have examined the developmental expression of the murine breast and ovarian cancer susceptibility gene, Brca1, to investigate its role in the control of cell growth and differentiation. Specifically, we have analysed Brca1 expression during embryonic development, in adult tissues, and during postnatal mammary gland development, particularly in response to ovarian hormones. Our results suggest that Brca1 is expressed in rapidly proliferating cell types undergoing differentiation. In the mammary gland, Brca1 expression is induced during puberty, pregnancy, and following treatment of ovariectomized animals with 17 beta-estradiol and progesterone. These observations imply that Brca1 is involved in the processes of proliferation and differentiation in multiple tissues, notably in the mammary gland in response to ovarian hormones.
我们研究了小鼠乳腺癌和卵巢癌易感基因Brca1的发育表达情况，以探究其在细胞生长和分化调控中的作用。具体而言，我们分析了Brca1在胚胎发育、成年组织以及出生后乳腺发育过程中的表达，特别是对卵巢激素的反应。我们的结果表明，Brca1在经历分化的快速增殖细胞类型中表达。在乳腺中，Brca1的表达在青春期、怀孕期以及用17β-雌二醇和孕酮处理去卵巢动物后被诱导。这些观察结果表明，Brca1参与多个组织的增殖和分化过程，尤其是在乳腺中对卵巢激素的反应。
