Veerkamp J H
Microbios. 1978;22(87):35-43.
Cell wall-inhibitory antibiotics caused a marked reduction of intracellular K+ and a small increase of Na+, together resulting in a decline of intracellular cation content. Chloramphenicol and tetracycline increased intracellular K+ but actinomycin decreased both Na+ and K+ content. The release and uptake of 86Rb+ were similarly affected by the antibiotics as the K+ content. The osmotic resistance of the protoplasts isolated from antibiotic-treated cells was apparently increased by inhibitors of cell wall synthesis, but decreased by inhibitors of protein synthesis. The ionophore valinomycin enhanced growth in normal and K+-rich medium, although cells released more than 90% of intracellular K+.
细胞壁抑制性抗生素导致细胞内钾离子显著减少，钠离子略有增加，共同导致细胞内阳离子含量下降。氯霉素和四环素增加细胞内钾离子，但放线菌素同时降低钠离子和钾离子含量。与钾离子含量类似，抗生素对86Rb+的释放和摄取也有相似影响。从经抗生素处理的细胞中分离出的原生质体的渗透压抗性，显然因细胞壁合成抑制剂而增加，但因蛋白质合成抑制剂而降低。离子载体缬氨霉素在正常培养基和富含钾离子的培养基中均能促进生长，尽管细胞释放了超过90%的细胞内钾离子。
