Kornhuber J, Weller M
Department of Psychiatry, University of Würzburg, Germany.
Convuls Ther. 1995 Jun;11(2):104-9.
The current practice of German psychiatric hospitals restricts electroconvulsive therapy (ECT) to patients with profound disability and failure to respond to pharmacotherapy. We studied clinical features and seizure parameters in 63 patients who received ECT in a 3-year period at a German university hospital. Patients with unipolar and bipolar disorder (depressed) (n = 47) showed a complete or partial recovery as assessed 2 weeks after completion of the ECT course in 31.9 and 38.3%, respectively. Multiple linear regression analysis performed on several clinical and ECT seizure parameters failed to identify strong outcome predictors in our selected sample of patients. Most patients who eventually responded did so early in the course of ECT, while there was little improvement when > 10 ECT treatments were given. Our report highlights the efficacy of ECT in the management of severe psychiatric disorders even in a highly selected sample of patients previously found to be resistant to alternative modes of psychiatric treatment.
德国精神病医院目前的做法是，仅对严重残疾且对药物治疗无反应的患者采用电休克疗法（ECT）。我们研究了在一家德国大学医院3年期间接受ECT治疗的63例患者的临床特征和癫痫发作参数。单相和双相情感障碍（抑郁发作）患者（n = 47）在ECT疗程结束2周后的评估显示，分别有31.9%和38.3%实现了完全或部分康复。对多个临床和ECT癫痫发作参数进行的多元线性回归分析未能在我们选定的患者样本中识别出强有力的预后预测因素。大多数最终有反应的患者在ECT疗程早期就出现了反应，而在接受超过10次ECT治疗后改善甚微。我们的报告强调了ECT在严重精神疾病治疗中的有效性，即使是在先前被发现对其他精神治疗方式耐药的高度精选患者样本中也是如此。
