Kawashima Y, Horiguchi A, Taguchi M, Tuyuki Y, Karasawa Y, Araki H, Hatayama K
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Chem Pharm Bull (Tokyo). 1995 May;43(5):783-7. doi: 10.1248/cpb.43.783.
A series of 1,2,3,4-tetrahydro-beta-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.
已合成了一系列1,2,3,4-四氢-β-咔啉，并评估了它们对小鼠脂质过氧化和氰化钾中毒的脑保护作用。大多数合成的化合物对脂质过氧化有显著作用。其中，1-(3,5-二甲氧基苯基)-2-丙基-1,2,3,4-四氢-β-咔啉(22)被发现对脂质过氧化和氰化钾中毒都有显著作用。讨论了构效关系。
