Nilsson E, Thomsen P, Ericson L, Palmblad J
Department of Medicine, Karolinska Institute, Stockholm Söder Hospital, Sweden.
Clin Exp Immunol. 1995 Oct;102(1):137-43. doi: 10.1111/j.1365-2249.1995.tb06647.x.
Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since chemiluminescent responses of peripheral blood PMN to opsonized zymosan and phorpbol myristate acetate (PMA) increased 6.4- and 17.9-fold, respectively. Chemiluminescent responses of synovial PMN were further amplified. This up-regulation was reduced to 33% in rabbits treated with ethanol when opsonized zymosan was used as the PMN stimulus; in contrast, PMA responses were unaffected. The appearance and migration of PMN to the synovitis joint were normal despite a blood ethanol concentration of 0.5%. Thus, ethanol impaired release of oxygen metabolites from PMN, but not the delivery of cells at an inflammatory site.
多形核粒细胞（PMN）的功能障碍被认为会导致酗酒者炎症反应受阻和宿主防御能力下降。我们研究了静脉注射乙醇对兔膝关节滑膜炎诱导过程中PMN反应的影响。滑膜炎具有全身效应，因为外周血PMN对调理酵母聚糖和佛波酯肉豆蔻酸酯（PMA）的化学发光反应分别增加了6.4倍和17.9倍。滑膜PMN的化学发光反应进一步增强。当用调理酵母聚糖作为PMN刺激物时，乙醇处理的兔中这种上调减少到33%；相比之下，PMA反应不受影响。尽管血液乙醇浓度为0.5%，PMN向滑膜炎关节的出现和迁移仍正常。因此，乙醇损害了PMN中氧代谢产物的释放，但不影响炎症部位细胞的输送。
