Crawford J P, Hickson G S, Ward M J
J Manipulative Physiol Ther. 1986 Dec;9(4):249-56.
The pathology of acute synovitis induced by immune complexes was investigated in this study. The reversed passive Arthus method of lesion induction was utilized, in conjunction with radiolabeled cell and protein markers, to quantitate inflammatory parameters and ascertain their kinetics in the synovial tissues of the rabbit. The rates of increased vessel permeability, polymorphonuclear leukocyte infiltration and platelet deposition were studied using 125-I-albumin, 51-CR-PMN-leukocytes and 111-In-platelets, respectively. Increase in vessel permeability over time was found to directly correlate with increased leukocyte infiltration (r = 9.08; P less than 0.01). Similar correlations between vascular permeability and platelet accumulation, and leukocyte infiltration and platelet accumulation, were not observed. The histological evaluation of synovial lesions corroborated the kinetic findings.
本研究对免疫复合物诱导的急性滑膜炎的病理学进行了研究。采用反向被动阿尔图斯损伤诱导方法，结合放射性标记的细胞和蛋白质标记物，对兔滑膜组织中的炎症参数进行定量，并确定其动力学。分别使用125-I-白蛋白、51-CR-PMN-白细胞和111-In-血小板研究血管通透性增加、多形核白细胞浸润和血小板沉积的速率。发现血管通透性随时间的增加与白细胞浸润的增加直接相关（r = 9.08；P小于0.01）。未观察到血管通透性与血小板积聚、白细胞浸润与血小板积聚之间的类似相关性。滑膜病变的组织学评估证实了动力学研究结果。
