Vittorio C C, Schiffman M H, Weinstock M A
Division of Dermatology, Brown University, Providence, Rhode Island, USA.
Dermatol Clin. 1995 Jul;13(3):561-74.
The inherent difficulties in the study of HPV infection have made the epidemiology of this common infection complex. The early natural history of HPV infection is similar for all genital and nongenital tissues. Genital HPV infection, however, especially cervical infection, is strongly linked to carcinoma. With the advent of molecular diagnosis of infection, and possible future serologic assays, the natural history of HPV-induced disease and its relationship to the development of invasive carcinoma can lead to more appropriate surveillance and treatment of patients at risk for progression.
人乳头瘤病毒（HPV）感染研究中存在的固有困难使得这种常见感染的流行病学变得复杂。HPV感染的早期自然史在所有生殖器和非生殖器组织中都相似。然而，生殖器HPV感染，尤其是宫颈感染，与癌症密切相关。随着感染分子诊断技术的出现以及未来可能的血清学检测方法，HPV所致疾病的自然史及其与浸润性癌发生发展的关系将有助于对有病情进展风险的患者进行更恰当的监测和治疗。
