Bradshaw C, Steen I N, Eccles M
Marsden Rd Health Centre, South Shields, UK.
Diabet Med. 1995 Jul;12(7):628-31. doi: 10.1111/j.1464-5491.1995.tb00554.x.
The aim of the study was to evaluate the level of control, as reflected by HbA1c, in patients with diabetes attending one general practice over a 10-year period. The study was based in one general practice in South Tyneside, UK and consisted of an analysis of HbA1c values of all patients with diabetes attending the practice between 1983 and 1992. HbA1c levels were analysed and are presented as multiples of the standard deviation above the mean. In the practice 256 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 76 with insulin-dependent diabetes mellitus (IDDM), attended for a total of 1596 doctor/patient contacts in the diabetic clinic over 10 years. The prevalence of diabetes was 1.9%. Over the course of the clinic, in any one year, 25% of patients with NIDDM and 55% with IDDM had levels of HbA1c above those thought to be associated with increased risk of microvascular complications. Significant reduction in glycated haemoglobin (HbA1c) occurred in the first year after diagnosis (p < 0.01) and after changing treatment from diet alone to diet and oral hypoglycaemic agents (p < 0.001). We conclude that a large proportion of patients within this population had levels of glycaemic control that put them 'at increased risk'.
该研究的目的是评估在10年期间就诊于一家普通诊所的糖尿病患者糖化血红蛋白（HbA1c）所反映的控制水平。该研究以英国南泰恩赛德的一家普通诊所为基础，对1983年至1992年间在该诊所就诊的所有糖尿病患者的HbA1c值进行了分析。对HbA1c水平进行了分析，并以高于均值的标准差倍数表示。在该诊所，256例非胰岛素依赖型糖尿病（NIDDM）患者和76例胰岛素依赖型糖尿病（IDDM）患者在10年期间共进行了1596次糖尿病诊所的医患接触。糖尿病患病率为1.9%。在诊所运营过程中，在任何一年，25%的NIDDM患者和55%的IDDM患者的HbA1c水平高于被认为与微血管并发症风险增加相关的水平。糖化血红蛋白（HbA1c）在诊断后的第一年（p<0.01）以及从单纯饮食治疗改为饮食加口服降糖药治疗后（p<0.001）出现显著下降。我们得出结论，该人群中很大一部分患者的血糖控制水平使他们“处于风险增加状态”。
