Beinert T, Brand P, Behr J, Vogelmeier C, Heyder J
GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, München, Germany.
Chest. 1995 Oct;108(4):998-1003. doi: 10.1378/chest.108.4.998.
Monodisperse aerosol particles can be used to assess noninvasively intrapulmonary airspace dimensions. Since emphysematic changes in the peripheral lung are difficult to detect with most of the common lung function tests, aerosol-derived airway morphometry was used to assess the peripheral airspace dimensions (EAD800) in 25 patients with COPD and in 36 healthy volunteers. Spirometric and body plethysmographic measurements were performed in all patients. In ten patients, high-resolution CT-derived mean lung density (MLD) was additionally assessed. In healthy subjects, EAD800 was 0.39 +/- 0.05 mm. In patients, EAD800 was significantly increased (0.82 +/- 0.33 mm). In a subset of nine patients with severe alpha 1-antitrypsin deficiency and clinically severe emphysema, EAD800 was even larger (1.14 +/- 0.32 mm). In patients, EAD800 correlated with MLD (r = 0.82), diffusion capacity (DCO) (r = 0.78), and FEV1 (r = -0.75). Since MLD is considered a valid indicator for lung emphysema, the close correlation between EAD800 and MLD suggests that EAD800 reflects enlarged peripheral airspace dimensions in patients with emphysema.
单分散气溶胶颗粒可用于无创评估肺内气腔尺寸。由于大多数常见肺功能测试难以检测到外周肺的肺气肿变化，因此采用气溶胶衍生气道形态测量法评估了25例慢性阻塞性肺疾病（COPD）患者和36名健康志愿者的外周气腔尺寸（EAD800）。对所有患者进行了肺活量测定和体容积描记测量。在10例患者中，还额外评估了高分辨率CT得出的平均肺密度（MLD）。在健康受试者中，EAD800为0.39±0.05毫米。在患者中，EAD800显著增加（0.82±0.33毫米）。在9例严重α1-抗胰蛋白酶缺乏且临床诊断为严重肺气肿的患者亚组中，EAD800甚至更大（1.14±0.32毫米）。在患者中，EAD800与MLD（r = 0.82）、弥散功能（DCO）（r = 0.78）和第1秒用力呼气容积（FEV1）（r = -0.75）相关。由于MLD被认为是肺气肿的有效指标，EAD800与MLD之间的密切相关性表明EAD800反映了肺气肿患者外周气腔尺寸的增大。
