Yang L, Zhang J, Liang G
Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an.
Zhonghua Yan Ke Za Zhi. 1995 May;31(3):215-7.
The authors reported the method of treatment of ocular malignant tumors at early and middle stages with local injections of self lymphokine-activated killing (LAK) cells which were induced by gamma IL-2 in vitro. Satisfactory therapeutic results were obtained. Among the 25 cases of ocular malignant tumors, 10 cases were treated only with IL-2 LAK cells, nine of them got complete regression (CR) and one got partial regression (PR); the other 15 cases were treated with operation and IL-2 LAK cells and they all obtained complete remission. In the follow-up, except the contact of 1 case with PR was lost, all the other 24 cases did not relapse after 1-5 years of observation. The above results show that the treatment of malignant tumors with local injection of self IL-2 LAK cells is a very effective immunotherapy.
作者报道了采用体外γ白细胞介素-2诱导的自身淋巴因子激活的杀伤细胞（LAK细胞）局部注射治疗眼恶性肿瘤早、中期的方法。获得了满意的治疗效果。在25例眼恶性肿瘤患者中，10例仅接受IL-2 LAK细胞治疗，其中9例完全缓解（CR），1例部分缓解（PR）；另外15例接受手术联合IL-2 LAK细胞治疗，均获得完全缓解。随访中，除1例PR患者失访外，其余24例经1 - 5年观察均未复发。上述结果表明，局部注射自身IL-2 LAK细胞治疗恶性肿瘤是一种非常有效的免疫疗法。
