Rossier Y, Divers T J, Sweeney R W
Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348, USA.
Equine Vet J. 1995 May;27(3):217-20. doi: 10.1111/j.2042-3306.1995.tb03065.x.
The urinary GGT/urinary creatinine (uGGT/uCR) ratio was measured on Days 1, 3 and 10 in 4 adult, healthy horses; in 6 adult, healthy horses treated with gentamicin at recommended dosages and 9 adult horses treated for pleuropneumonia with gentamicin at recommended dosages. Plasma creatinine and gentamicin trough concentrations were measured on the same days. The uGGT/uCr ratio was higher in the normal horses (mean +/- s.d. 22.85 +/- 13.69) than previously reported normal values (10.5 +/- 6.8) (Adams and McClure 1985). Analysis of variance for repeated measures was used to compare the ratio in the 3 groups while controlling for the effect of time. Sick horses had a significantly higher uGGT/uCr ratio than either of the 2 groups of normal horses. Both groups of horses that were treated with gentamicin had similar percentage increases in uGGT/uCr ratio over the treatment period with the most marked increases found between treatment Days 1 and 3. The increase in uGGT/Cr ratio was predominantly a result of an increase in uGGT activity rather than a decrease in uCr concentration. The increase in uGGT activity and uGGT/uCr ratio occurred without abnormalities in serum creatinine or gentamicin trough concentrations. These findings demonstrate that urine GGT activity and uGGT/uCr ratio should be expected to increase in response to gentamicin therapy at recommended dosages without measurable changes in serum creatinine. This suggests that an elevation of the uGGT/uCr ratio in horses being treated with gentamicin would not necessarily require changes in, or withdrawal of, the gentamicin treatment as long as increases in the plasma creatinine do not exceed 0.3 g/l and gentamicin trough concentrations are < 2 micrograms/l.
在4匹成年健康马、6匹按推荐剂量用庆大霉素治疗的成年健康马以及9匹按推荐剂量用庆大霉素治疗胸膜肺炎的成年马中，于第1天、第3天和第10天测量尿γ-谷氨酰转移酶/尿肌酐（uGGT/uCR）比值。在同一天测量血浆肌酐和庆大霉素谷浓度。正常马的uGGT/uCr比值（均值±标准差为22.85±13.69）高于先前报道的正常数值（10.5±6.8）（亚当斯和麦克卢尔，1985年）。采用重复测量方差分析来比较3组的比值，同时控制时间效应。患病马的uGGT/uCr比值显著高于两组正常马中的任何一组。两组用庆大霉素治疗的马在治疗期间uGGT/uCr比值的百分比升高相似，在治疗第1天和第3天之间升高最为明显。uGGT/Cr比值的升高主要是由于uGGT活性增加，而非uCr浓度降低。uGGT活性和uGGT/uCr比值升高，而血清肌酐或庆大霉素谷浓度无异常。这些发现表明，按推荐剂量使用庆大霉素治疗时，尿GGT活性和uGGT/uCr比值应会升高，而血清肌酐无可测量的变化。这表明，在用庆大霉素治疗的马中，只要血浆肌酐升高不超过0.3 g/l且庆大霉素谷浓度<2微克/升，uGGT/uCr比值升高不一定需要改变或停用庆大霉素治疗。
