氧气鼓泡可改善五价锝-99m二巯基丁二酸的标记。
Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.
作者信息
Kobayashi H, Suzuki K H, Sakahara H, Yao Z S, Yokoyama A, Konishi J
机构信息
Department of Nuclear Medicine, Kyoto University, Faculty of Medicine, Japan.
出版信息
Eur J Nucl Med. 1995 Jun;22(6):559-62. doi: 10.1007/BF00817283.
It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (99mTc (V) DMSA) can be changed into 99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of 99mTc. The method of labelling of 99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated 99mTc (III) DMSA into 99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.
此前有报道称，通过用纯氧鼓泡，几乎所有存在于五价锝-99m二巯基丁二酸（99mTc (V) DMSA）标记产物中的三价锝-99m二巯基丁二酸（99mTc (III) DMSA）都可转变为99mTc (V) DMSA。因此，我们在动物（小鼠）和人类身上进行了研究，以调查这种氧鼓泡对99mTc标记效率及肾脏摄取的影响。99mTc (V) DMSA的标记方法采用平野法。结果发现，氧鼓泡在体外将受污染的99mTc (III) DMSA氧化为99mTc (V) DMSA，并降低了动物和人类肾脏中的放射性摄取。
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