Franco-Cereceda A, Barr G, Owall A, Liska J, Lundberg J M
Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
Eur J Pharmacol. 1995 Jun 6;279(1):105-7. doi: 10.1016/0014-2999(95)00213-5.
Following reperfusion of ischaemic human hearts subjected to cold (4 degrees C) cardioplegia during coronary bypass surgery, there was an increase in cardiac outflow of endothelin-1 but not the pro-peptide big endothelin-1. Furthermore, specific endothelin-1 binding in human lung membrane preparations was displaced by incubation in buffer medium at 4 degrees C. The present results thus indicate that cold-induced displacement of endothelin-1 binding, rather than increased synthesis, may explain the cardiac release of endothelium-1 following ischaemia during heart surgery in which cold cardioplegia has been used.
在冠状动脉搭桥手术中，对经历冷（4℃）心脏停搏的缺血性人类心脏进行再灌注后，内皮素-1的心脏流出量增加，而前体肽大内皮素-1的流出量未增加。此外，人肺膜制剂中的特异性内皮素-1结合在4℃的缓冲介质中孵育后被置换。因此，目前的结果表明，冷诱导的内皮素-1结合置换，而非合成增加，可能解释了在使用冷心脏停搏的心脏手术期间缺血后内皮素-1的心脏释放。
