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钙黏蛋白在发育中的脊椎动物中枢神经系统中的表达:从神经节段到脑核团及神经回路

Cadherin expression in the developing vertebrate CNS: from neuromeres to brain nuclei and neural circuits.

作者信息

Redies C

机构信息

Department of Biochemistry, Max-Planck-Institute for Developmental Biology, Tübingen, Germany.

出版信息

Exp Cell Res. 1995 Oct;220(2):243-56. doi: 10.1006/excr.1995.1313.

Abstract

Cadherins are a family of cell surface glycoproteins which mediate cell-cell adhesion by a Ca(2+)-dependent mechanism. Results from in vitro studies with cadherin-transfected cell lines show that cadherins preferentially bind to each other in a homophilic fashion. In the developing vertebrate brain, at least 10 cadherins are found. Some of these cadherins are expressed in a restricted fashion in particular developing brain nuclei and neural circuits. Based on these results, specific morphogenetic roles for cadherins during CNS development have been proposed. This review focuses on the possible role of cadherin-mediated sorting and aggregation of early neurons and neurites in the formation of brain nuclei, fiber tracts, and neural circuits. Moreover, at least 1 cadherin is also expressed in a segmental ("neuromeric") fashion in the early chicken forebrain, suggesting that this cadherin regulates developmental processes involved in the transformation from the neuromeric organization of the early neuroepithelium to the functional organization of the mature brain.

摘要

钙黏蛋白是一类细胞表面糖蛋白,通过钙依赖机制介导细胞间黏附。对转染钙黏蛋白的细胞系进行的体外研究结果表明,钙黏蛋白以嗜同性方式优先相互结合。在发育中的脊椎动物大脑中,发现了至少10种钙黏蛋白。其中一些钙黏蛋白在特定发育中的脑核和神经回路中以受限方式表达。基于这些结果,有人提出了钙黏蛋白在中枢神经系统发育过程中的特定形态发生作用。本综述重点关注钙黏蛋白介导的早期神经元和神经突的分选和聚集在脑核、纤维束和神经回路形成中的可能作用。此外,至少有一种钙黏蛋白在早期鸡前脑中也以节段性(“神经节段性”)方式表达,这表明这种钙黏蛋白调节了参与从早期神经上皮的神经节段性组织向成熟大脑功能组织转变的发育过程。

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