Wei L N, Lee C H, Chang L
Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA.
Mol Cell Endocrinol. 1995 Jun;111(2):207-11. doi: 10.1016/0303-7207(95)03570-w.
Cellular retinoic acid-binding protein-I (CRABP-I) gene expression is induced in mouse embryonal carcinoma P19 cells specifically by retinoic acid (RA) and the induction is enhanced by sphinganine. The effects of retinoic acid and sphinganine on CRABP-I gene expression can be accounted for by a stimulation of its transcription rate. Using a lacZ reporter system, it was determined that a DNA fragment containing a putative AP-1 binding site in the promoter region of CRABP-I gene is required for the up-regulation of CRABP-I gene transcription.
细胞视黄酸结合蛋白-I（CRABP-I）基因表达在小鼠胚胎癌细胞P19中由视黄酸（RA）特异性诱导，且鞘氨醇可增强这种诱导作用。视黄酸和鞘氨醇对CRABP-I基因表达的影响可通过刺激其转录速率来解释。使用lacZ报告系统确定，CRABP-I基因启动子区域中包含一个假定的AP-1结合位点的DNA片段是CRABP-I基因转录上调所必需的。
