腺苷类药物对大鼠阿扑吗啡诱导的舔舐行为的影响。

Effects of adenosine drugs on apomorphine-induced licking in rats.

Zarrindast M R, Sharifzadeh M

Department of Pharmacology, School of Medicine, University of Tehran, Iran.

Gen Pharmacol. 1995 Sep;26(5):1119-23. doi: 10.1016/0306-3623(94)00274-q.

Abstract

In the present work, the effect of adenosine agonists and antagonists on apomorphine-induced licking has been studied. 2. Subcutaneous (s.c.) injection of apomorphine (0.125, 0.25 and 0.5 mg/kg) produced dose-dependent licking in rats. 3. Adenosine agonists 5'-N-ethylcarboxamide-adenosine (NECA) and N6-cyclohexyladenosine (CHA) decreased or increased the apomorphine response respectively. 4. Adenosine antagonists theophylline and 8-phenyltheophylline (8-PT) decreased the response induced by apomorphine. Potentiation of licking induced by CHA was decreased by 8-PT pretreatment. 5. It is concluded that adenosine receptors may be involved in the licking behaviour.

摘要

在本研究中，已对腺苷激动剂和拮抗剂对阿扑吗啡诱导的舔舐行为的影响进行了研究。2. 皮下注射阿扑吗啡（0.125、0.25和0.5毫克/千克）在大鼠中产生了剂量依赖性的舔舐行为。3. 腺苷激动剂5'-N-乙基羧酰胺腺苷（NECA）和N6-环己基腺苷（CHA）分别降低或增强了阿扑吗啡反应。4. 腺苷拮抗剂茶碱和8-苯基茶碱（8-PT）降低了阿扑吗啡诱导的反应。8-PT预处理降低了CHA诱导的舔舐增强作用。5. 得出的结论是，腺苷受体可能参与了舔舐行为。