与大肠杆菌菌毛编码区相关的溶血活性
Dr fimbriae coding region associated hemolytic activity of Escherichia coli.
作者信息
Goluszko P, Nowicki S, Kaul A K, Pham T, Nowicki B J
机构信息
University of Texas Medical Branch at Galveston, Department of Obstetics and Gynecology 77555-1062, USA.
出版信息
FEMS Microbiol Lett. 1995 Jul 15;130(1):13-7. doi: 10.1016/0378-1097(95)00177-7.
We investigated the hemolytic activity of Escherichia coli strain EC901 carrying plasmid pBJN406 containing genes draA-E involved in expression of the mannose-resistant Dr hemagglutinin, and in its isogenic insertion mutants devised with Tn5, Tn3, and TnphoA. While E. coli BN406 displayed rapid hemolytic activity against equine erythrocytes, insertion mutations in draD and draE, but not in draA, draB, and draC, abolished all hemolytic activity. These data suggest a role for draD and draE in the expression of hemolysis.
我们研究了携带质粒pBJN406的大肠杆菌菌株EC901的溶血活性，该质粒含有参与甘露糖抗性Dr血凝素表达的draA - E基因，以及用Tn5、Tn3和TnphoA构建的其同基因插入突变体的溶血活性。虽然大肠杆菌BN406对马红细胞表现出快速溶血活性，但draD和draE中的插入突变（而非draA、draB和draC中的插入突变）消除了所有溶血活性。这些数据表明draD和draE在溶血表达中发挥作用。
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