母体糖尿病对自发性高血压大鼠后代寿命的影响。

Effect of maternal diabetes on longevity in offspring of spontaneously hypertensive rats.

作者信息

Iwase M, Wada M, Shinohara N, Yoshizumi H, Yoshinari M, Fujishima M

机构信息

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Gerontology. 1995;41(4):181-6. doi: 10.1159/000213680.

DOI:10.1159/000213680

PMID:7557494

Abstract

We studied the effect of maternal diabetes induced by neonatal streptozotocin treatment on the longevity of the male offspring in spontaneously hypertensive rats (SHR). Maternal diabetes significantly decreased the survival in the offspring as compared with the control (p < 0.01). Mean age at death was 14.9 +/- 0.6 months in the offspring from the diabetic dams and 17.9 +/- 1.1 months in that from the control. The life span was significantly correlated with the birth weight (rs = 0.55, p = 0.009). These findings suggest that a diabetic pregnancy may accelerate an age-related degenerative process of the offspring in SHR.

摘要

我们研究了新生大鼠经链脲佐菌素处理诱导的母体糖尿病对自发性高血压大鼠（SHR）雄性后代寿命的影响。与对照组相比，母体糖尿病显著降低了后代的存活率（p < 0.01）。糖尿病母鼠后代的平均死亡年龄为14.9±0.6个月，对照组后代为17.9±1.1个月。寿命与出生体重显著相关（rs = 0.55，p = 0.009）。这些发现表明，糖尿病妊娠可能会加速SHR后代与年龄相关的退行性进程。