多巴胺拮抗剂（甲氧氯普胺）对高催乳素血症性闭经女性β-内啡肽、促肾上腺皮质激素和皮质醇释放的影响。

Effects of a dopamine antagonist (metoclopramide) on the release of beta-endorphin, ACTH and cortisol in hyperprolactinemic-amenorrheic women.

作者信息

Seki K, Mitsui C, Nagata I

机构信息

Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.

出版信息

Gynecol Obstet Invest. 1995;40(1):42-5. doi: 10.1159/000292300.

DOI:10.1159/000292300

PMID:7557642

Abstract

Responses of LH, TSH, PRL, beta-endorphin-like immunoreactivity, ACTH and cortisol to metoclopramide were evaluated in hyperprolactinemic-amenorrheic women and normal women. Augmented TSH responses and blunted PRL responses to metoclopramide were found in hyperprolactinemic women compared to normal women. A significant increase in serum LH levels was found only in hyperprolactinemic women after metoclopramide. Thus, the hyperprolactinemic women showed hormonal changes compatible with increased central dopaminergic tone. A significant increase in circulating levels of beta-endorphin-like immunoreactivity, ACTH and cortisol was found in hyperprolactinemic women but not in normal women after metoclopramide administration. Thus, beta-endorphin and ACTH secretion appear to be tonically inhibited by increased central dopaminergic tone in hyperprolactinemic-amenorrheic women.

摘要

在高催乳素血症性闭经女性和正常女性中评估了促黄体生成素（LH）、促甲状腺激素（TSH）、催乳素（PRL）、β-内啡肽样免疫反应性、促肾上腺皮质激素（ACTH）和皮质醇对甲氧氯普胺的反应。与正常女性相比，高催乳素血症女性对甲氧氯普胺的TSH反应增强，PRL反应减弱。仅在高催乳素血症女性中，甲氧氯普胺给药后血清LH水平显著升高。因此，高催乳素血症女性表现出与中枢多巴胺能张力增加相符的激素变化。在高催乳素血症女性中，甲氧氯普胺给药后循环中的β-内啡肽样免疫反应性、ACTH和皮质醇水平显著升高，但正常女性中未出现这种情况。因此，在高催乳素血症性闭经女性中，β-内啡肽和ACTH的分泌似乎受到中枢多巴胺能张力增加的持续性抑制。