Nishimura N, Takase H, Morita T
New Drug Research Laboratories, Kanebo, Ltd., Osaka, Japan.
Nihon Yakurigaku Zasshi. 1995 Jun;105(6):479-89. doi: 10.1254/fpj.105.479.
To compare the effects of an angiotensin II (Ang II)-receptor antagonist and an angiotensin-converting enzyme (ACE) inhibitor on myocardial, vascular structure and reactivity, SHR (5-week-old) were treated with losartan of captoril for 16 weeks. Losartan (10 mg/kg/day, p.o.) and captopril (30 mg/kg/day, p.o.) significantly prevented the development of hypertension with aging, and the effects by these drugs were almost similar. Losartan and captopril significantly reduced the ventricular weight and the thickening of the coronary artery. Maximal coronary flow (MCF) induced by adenosine in the isolated heart was significantly higher in both the losartan and captopril groups. However, MCF in the captopril group was significantly lower than that in the losartan group. The pressor response to exogenous norepinephrine in the mesenteric arterial bed was significantly lower in the losartan group, whereas that in the captopril group was not. These findings suggest that the local Ang II produced by enzymes other than ACE also may play a role in vascular hypertrophy and hyperresponsiveness in SHR.
为比较血管紧张素II（Ang II）受体拮抗剂和血管紧张素转换酶（ACE）抑制剂对心肌、血管结构及反应性的影响，对5周龄的自发性高血压大鼠（SHR）用氯沙坦或卡托普利治疗16周。氯沙坦（10毫克/千克/天，口服）和卡托普利（30毫克/千克/天，口服）均能显著阻止高血压随年龄的发展，且这两种药物的效果几乎相似。氯沙坦和卡托普利均能显著减轻心室重量和冠状动脉增厚。氯沙坦组和卡托普利组中，腺苷在离体心脏中诱导的最大冠脉血流量（MCF）均显著升高。然而，卡托普利组的MCF显著低于氯沙坦组。氯沙坦组中，肠系膜动脉床对外源性去甲肾上腺素的升压反应显著降低，而卡托普利组则无此现象。这些发现表明，由ACE以外的酶产生的局部Ang II也可能在SHR的血管肥大和高反应性中起作用。
