Zimmer J E, Hynynen K, He D S, Marcus F
Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724, USA.
IEEE Trans Biomed Eng. 1995 Sep;42(9):891-7. doi: 10.1109/10.412655.
The feasibility of using ultrasound to induce cardiac tissue necrosis for the treatment of arrhythmias was investigated. A theoretical model was used to optimize the operating frequency for necrosis of highly perfused muscle tissue. From these simulations it appeared that frequencies from 10-15 MHz produce the deepest lesions at ultrasound intensities between 15 and 30 W/cm2. Test catheters with a planar ultrasound transducer (diameter 2.3 mm = 7 F) were also constructed and in vitro and in vivo tests with canine heart muscle were performed. Both of these tests showed that the ultrasound catheters could deliver adequate energy to necrose cardiac tissue. The in vivo lesion depths of 5-9 mm indicated that ultrasound has significant potential for cardiac ablation for the treatment of arrhythmias.
研究了使用超声诱导心脏组织坏死以治疗心律失常的可行性。使用理论模型来优化用于高度灌注肌肉组织坏死的工作频率。从这些模拟结果来看，10 - 15兆赫兹的频率在15至30瓦/平方厘米的超声强度下能产生最深的损伤。还构建了带有平面超声换能器（直径2.3毫米 = 7F）的测试导管，并对犬类心肌进行了体外和体内测试。这两项测试均表明，超声导管能够输送足够的能量使心脏组织坏死。体内损伤深度为5 - 9毫米，表明超声在用于治疗心律失常的心脏消融方面具有巨大潜力。
