减毒免疫原性寄生虫对于将免疫力传递给恶性疟原虫至关重要。
Attenuated immunogenic parasites are essential in the transfer of immunity to virulent Plasmodium berghei.
作者信息
Celluzzi C M, Liem P L, van de Wiel T, Eling W M
机构信息
Department of Medical Parasitology, Faculty of Medicine, Catholic University of Nijmegen, The Netherlands.
出版信息
Immunology. 1995 Jul;85(3):509-15.
A less virulent parasite of Plasmodium berghei K173 was isolated that induced immunity against the more virulent parasite. Immunity to this parasite but not to the virulent one, could be transferred by immune spleen cells but not by immune lymph node cells. However, the immune spleen cells did transfer immunity to the virulent strain if accompanied by infection with viable parasites of the less virulent strain, but only if they were allowed to proliferate for a period of 1 week before challenge with the virulent strain. Immune spleen cells could survive two cycles of mouse to mouse transfer. The induction of immunity by transfer of immune spleen cells was associated with the production of anti-parasitic antibody.
分离出了一种毒性较低的伯氏疟原虫K173寄生虫，它能诱导针对毒性更强的寄生虫的免疫力。对这种寄生虫而非毒性强的寄生虫的免疫力，可以通过免疫脾细胞传递，但不能通过免疫淋巴结细胞传递。然而，如果伴有感染毒性较低的活寄生虫，免疫脾细胞确实能将免疫力传递给毒性强的菌株，但前提是在受到毒性强的菌株攻击之前，它们要增殖1周时间。免疫脾细胞能够在小鼠间进行两轮传递存活下来。通过免疫脾细胞传递诱导的免疫力与抗寄生虫抗体的产生有关。
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