在一个与世隔绝的纽芬兰人群中HLA单倍型个体的Bf类型

Bf types of HLA haplotyped individuals in an isolated Newfoundland population.

作者信息

Larsen B, Arnason A, Barnard J M, Buehler S K, Edwards J H, Marshall W H

出版信息

Tissue Antigens. 1977 Nov;10(5):403-9. doi: 10.1111/j.1399-0039.1977.tb00777.x.

DOI:10.1111/j.1399-0039.1977.tb00777.x

Abstract

Five hundred and fourteen individuals from an isolated NewFoundland population have been typed and haplotyped for HLA and Factor B (Bf locus). The Bf gene frequencies were: S0.704, F0.226, F1 0.052 and S1 0.018. Tracing the haplotypes backwards on the various pedigrees it was shown that 202 HLA/Bf haplotypes had been introduced into the study population. Some HLA alleles always appeared in association with particular Bf alleles and vice versa. Bf S1 had entered the population four times, always with HLA--A9, B12. Bf F1 had entered three times, always with HLA--B18. There were 17 entries of HLA--Al, B8 that had given rise to the 78 such haplotypes that were now present in the population; all were Bf S. There were 68 family units informative for Bf. They accounted for 240 children and 304 informative meioses. There were three recombinants in the HLA region but none could be shown to have occurred between the HLA-B and Bf loci.

摘要

对来自纽芬兰一个孤立人群的514人进行了HLA和B因子（Bf位点）的分型和单倍型分析。Bf基因频率分别为：S 0.704、F 0.226、F1 0.052和S1 0.018。在各个家系中追溯单倍型发现，有202种HLA/Bf单倍型被引入研究人群。一些HLA等位基因总是与特定的Bf等位基因同时出现，反之亦然。Bf S1四次进入该人群，总是与HLA - A9、B12同时出现。Bf F1三次进入该人群，总是与HLA - B18同时出现。有17次HLA - A1、B8的进入产生了该人群中现有的78种此类单倍型；均为Bf S。有68个家系单位对Bf具有信息价值。它们涉及240名儿童和304次有信息价值的减数分裂。在HLA区域有三个重组体，但没有一个显示发生在HLA - B和Bf位点之间。