Bertrams J, Baur M P
Tissue Antigens. 1979 Oct;14(4):317-24. doi: 10.1111/j.1399-0039.1979.tb00855.x.
Altogether 1,072 HLA-A, B, Bf haplotypes in 536 parents of 268 German families were analyzed by gene and haplotype counting in order to investigate the two and three point association of HLA-A and B antigens with Bf alleles. In agreement with previously published data (Albert et al. 1975, Bender et al. 1977) significant positive linkage disequilibria were found for HLA-A3 and BfF, B7 and BfS, B8 and BfS, Bw35 and BfF, whereas significant negative Delta values appeared to exist for HLA-A3 and BfS, B7 and BfF, B8 and BfF, B12 and BfS, as well as Bw35 and BfS. Significant positive three point Delta values were found for the following haplotypes: HLA-A11, Bw35, BfS, HLA-Aw23, Bw35, BfS, HLA-A28, B12, BfS, HLA-A2, B17, BF, HLA-A3, Bw35, BfF, HLA-Aw24, b12, BfF and HLA-A29, B12, BfF. According to the large number of comparisons performed calculating the level of significance of the three point associations, these data have to be corroborated by further investigation. The three point Delta values, obtained by calculation from the patients' phenotypes differed markedly from those results obtained by haplotype counting.
为了研究HLA - A和B抗原与Bf等位基因的两点和三点关联，对268个德国家庭的536名父母中的总共1072个HLA - A、B、Bf单倍型进行了基因和单倍型计数分析。与先前发表的数据（Albert等人，1975年；Bender等人，1977年）一致，发现HLA - A3与BfF、B7与BfS、B8与BfS、Bw35与BfF之间存在显著的正连锁不平衡，而HLA - A3与BfS、B7与BfF、B8与BfF、B12与BfS以及Bw35与BfS之间似乎存在显著的负Delta值。对于以下单倍型发现了显著的正三点Delta值：HLA - A11、Bw35、BfS，HLA - Aw23、Bw35、BfS，HLA - A28、B12、BfS，HLA - A2、B17、BF，HLA - A3、Bw35、BfF，HLA - Aw24、b12、BfF和HLA - A29、B12、BfF。根据进行的大量比较来计算三点关联的显著性水平，这些数据必须通过进一步研究来证实。通过从患者表型计算得到的三点Delta值与通过单倍型计数获得的结果明显不同。
