Moses M A, Klagsbrun M, Shing Y
Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA.
Int Rev Cytol. 1995;161:1-48. doi: 10.1016/s0074-7696(08)62495-x.
The control of vascular growth and differentiation is a complex system of activity and interaction between positive and negative modulators of these processes. A number of important stimulators and inhibitors of both smooth muscle cells and endothelial cells have now been purified and biochemically characterized. Imbalances in the activity of these factors can result in serious pathologies. In this chapter, we briefly discuss the biology of blood vessel development and growth, review the current literature which describes these stimulators and inhibitors, and discuss current therapeutic strategies designed around these growth modulators.
血管生长与分化的调控是一个由这些过程的正负调节因子之间的活性和相互作用所构成的复杂系统。目前，平滑肌细胞和内皮细胞的一些重要刺激因子和抑制因子已被纯化并进行了生化特性分析。这些因子活性的失衡会导致严重的病理状况。在本章中，我们将简要讨论血管发育与生长的生物学特性，回顾描述这些刺激因子和抑制因子的现有文献，并探讨围绕这些生长调节因子设计的当前治疗策略。
