Spiro J D, Soo K C, Spiro R H
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Head Neck. 1995 Mar-Apr;17(2):114-8. doi: 10.1002/hed.2880170207.
Nonsquamous cell malignant tumors of the nasal cavity and paranasal sinuses are an uncommon and diverse group of neoplasms. Our goal was to define the relative frequency and distribution of these neoplasms, as well as treatment and outcome.
This retrospective study analyzed 106 patients with nonsquamous cell malignant neoplasms of the nasal cavity and paranasal sinuses treated at our institution between 1966 and 1982.
Pathology included: salivary type carcinoma (33 patients); sarcoma (25 patients); melanoma (18 patients); esthesioneuroblastoma (11 patients); lymphoma (11 patients); and anaplastic cancer (9 patients). Most tumors arose in the nasal cavity (50%), followed by the antrum (39%), ethmoid sinus (9%), and frontal sinus (2%). Fifty-four percent of all patients were treated with surgery alone. Determinate 5-year and 10-year cure rates were: esthesioneuroblastoma, 70% and 50%; lymphoma, 45% and 30%; anaplastic, 33% and 25%; salivary, 31% and 18%; sarcoma, 25% and 21%; and melanoma, 19% and 0%.
Overall survival for patients with nonsquamous cell malignant neoplasms of the nasal cavity and paranasal sinuses is poor, particularly with follow-up extended to 10 years. Local recurrence is the major source of treatment failure. We were unable to demonstrate any survival advantage in the group of patients who received surgery and radiotherapy in combination.
鼻腔和鼻窦的非鳞状细胞恶性肿瘤是一组罕见且多样的肿瘤。我们的目标是确定这些肿瘤的相对发病率和分布情况，以及治疗方法和预后。
这项回顾性研究分析了1966年至1982年间在我们机构接受治疗的106例鼻腔和鼻窦非鳞状细胞恶性肿瘤患者。
病理类型包括：涎腺型癌（33例）；肉瘤（25例）；黑色素瘤（18例）；嗅神经母细胞瘤（11例）；淋巴瘤（11例）；未分化癌（9例）。大多数肿瘤发生在鼻腔（50%），其次是上颌窦（39%）、筛窦（9%）和额窦（2%）。所有患者中有54%仅接受了手术治疗。确定的5年和10年治愈率分别为：嗅神经母细胞瘤，70%和50%；淋巴瘤，45%和30%；未分化癌，33%和25%；涎腺型癌，31%和18%；肉瘤，25%和21%；黑色素瘤，19%和0%。
鼻腔和鼻窦非鳞状细胞恶性肿瘤患者的总体生存率较差，尤其是随访延长至10年时。局部复发是治疗失败的主要原因。我们未能证明接受手术和放疗联合治疗的患者组有任何生存优势。
