Spiro J D, Soo K C, Spiro R H
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Am J Surg. 1989 Oct;158(4):328-32. doi: 10.1016/0002-9610(89)90127-x.
This study retrospectively analyzed 105 patients with squamous carcinoma of the nasal cavity and paranasal sinuses. The primary tumor was located in the maxillary sinus in 65 patients (62 percent), the nasal cavity in 27 (26 percent), the ethmoid sinus in 11 (10 percent), and the sphenoid sinus in 2 (2 percent). Over half of the patients with antral cancer were treated with surgery and radiotherapy, whereas one-third of the remaining patients received combination therapy. Most procedures were radical, including sacrifice of the orbital contents in half of the surgically treated patients. The 5-year determinate cure rate was 45 percent for patients with nasal cavity tumors, 38 percent for those with maxillary sinus lesions, and 13 percent for those with ethmoid tumors. Local recurrence remains a major problem despite aggressive surgery and increased use of adjunctive radiotherapy.
本研究回顾性分析了105例鼻腔及鼻窦鳞状细胞癌患者。原发肿瘤位于上颌窦65例（62%），鼻腔27例（26%），筛窦11例（10%），蝶窦2例（2%）。超过半数的上颌窦癌患者接受了手术和放疗，其余患者中有三分之一接受了联合治疗。大多数手术为根治性手术，包括一半接受手术治疗的患者切除眼眶内容物。鼻腔肿瘤患者的5年确定性治愈率为45%，上颌窦病变患者为38%，筛窦肿瘤患者为13%。尽管进行了积极的手术并增加了辅助放疗的使用，但局部复发仍然是一个主要问题。
