Takata H, Sada M, Ozawa S, Sekiguchi S
Tissue Antigens. 1978 Jan;11(1):61-4. doi: 10.1111/j.1399-0039.1978.tb01225.x.
A total of 60 leprosy patients, 28 of lepromatous and 32 of tuberculoid form, and 70 active tuberculosis patients was compared with a control of 184 for 34 HLA specificities. The most interesting finding was an increased frequency (10.0%) for HLA-B8 (corrected P = 0.062, relative risk = 20.3) in the leprosy patients as compared with the control group, despite the fact that the frequency of HLA-B8 was extremely low in Japanese. Furthermore, all leprosy patients with B8 had leprous member(s) in their family.
共对60例麻风患者(28例瘤型和32例结核样型)、70例活动性肺结核患者以及184例对照者进行了34种HLA特异性检测。最有趣的发现是,与对照组相比,麻风患者中HLA - B8的频率增加(10.0%)(校正P = 0.062,相对风险 = 20.3),尽管在日本人中HLA - B8的频率极低。此外,所有携带B8的麻风患者家族中都有麻风病患者。