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人类白细胞抗原(HLA)与分枝杆菌感染:日本麻风病患者中B8频率增加。

HLA and mycobacterial infection: increased frequency of B8 in Japanese leprosy.

作者信息

Takata H, Sada M, Ozawa S, Sekiguchi S

出版信息

Tissue Antigens. 1978 Jan;11(1):61-4. doi: 10.1111/j.1399-0039.1978.tb01225.x.

DOI:10.1111/j.1399-0039.1978.tb01225.x
PMID:75590
Abstract

A total of 60 leprosy patients, 28 of lepromatous and 32 of tuberculoid form, and 70 active tuberculosis patients was compared with a control of 184 for 34 HLA specificities. The most interesting finding was an increased frequency (10.0%) for HLA-B8 (corrected P = 0.062, relative risk = 20.3) in the leprosy patients as compared with the control group, despite the fact that the frequency of HLA-B8 was extremely low in Japanese. Furthermore, all leprosy patients with B8 had leprous member(s) in their family.

摘要

共对60例麻风患者(28例瘤型和32例结核样型)、70例活动性肺结核患者以及184例对照者进行了34种HLA特异性检测。最有趣的发现是,与对照组相比,麻风患者中HLA - B8的频率增加(10.0%)(校正P = 0.062,相对风险 = 20.3),尽管在日本人中HLA - B8的频率极低。此外,所有携带B8的麻风患者家族中都有麻风病患者。

相似文献

1
HLA and mycobacterial infection: increased frequency of B8 in Japanese leprosy.人类白细胞抗原(HLA)与分枝杆菌感染:日本麻风病患者中B8频率增加。
Tissue Antigens. 1978 Jan;11(1):61-4. doi: 10.1111/j.1399-0039.1978.tb01225.x.
2
Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system.通过人类白细胞抗原(HLA)系统分析日本麻风病患者的免疫遗传背景。
Vox Sang. 1982;42(5):243-7. doi: 10.1111/j.1423-0410.1982.tb00751.x.
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HLA antigen and susceptibility to leprosy.人类白细胞抗原(HLA)抗原与麻风易感性
Int J Lepr Other Mycobact Dis. 1977 Jul-Sep;45(3):273-7.
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Tuberculoid leprosy and HLA in Japanese.日本的结核样型麻风与人类白细胞抗原
Tissue Antigens. 1981 Nov;18(5):331-4. doi: 10.1111/j.1399-0039.1981.tb01400.x.
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The HLA antigens and leprosy in Thailand.泰国的人类白细胞抗原与麻风病
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[HLA and leprosy in Dakar: distribution of histocompatibility antigens in leprous patients and their relationship to ENL reactions].
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The HLA system and leprosy in Thailand.泰国的人类白细胞抗原系统与麻风病
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Histocompatibility antigens in patients with leprosy from Azarbaijan, Iran.来自伊朗阿塞拜疆的麻风病患者的组织相容性抗原
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Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil.人类白细胞抗原I类和II类等位基因与巴西东南部界线类麻风患者的易感性和抵抗力相关。
BMC Infect Dis. 2015 Jan 21;15:22. doi: 10.1186/s12879-015-0751-0.
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The HLA system and leprosy in Thailand.
泰国的人类白细胞抗原系统与麻风病
Hum Genet. 1978 Jun 9;42(2):201-13. doi: 10.1007/BF00283640.