Chiba A, Kusunoki S, Kuwata S, Juji T, Shibata Y, Kanazawa I
Department of Neurology, School of Medicine, University of Tokyo, Japan.
J Neuroimmunol. 1995 Aug;61(1):85-8. doi: 10.1016/0165-5728(95)00079-h.
We investigated serological human leukocyte antigen (HLA) types in patients with histories of Miller Fisher syndrome (MFS) and Guillain-Barré syndrome (GBS) with ophthalmoplegia, in whom serum anti-GQ1b IgG antibody was present during the acute phase. We examined class I antigens (A, B and C) in 32 patients and class II antigens (DR and DQ) in 30, but found no association. We conclude that particular serologically defined HLA types are not preferred for the immunoresponse of anti-GQ1b IgG antibody in MFS and GBS.
我们调查了有米勒-费雪综合征（MFS）病史以及伴有眼肌麻痹的吉兰-巴雷综合征（GBS）患者的血清学人类白细胞抗原（HLA）类型，这些患者在急性期存在血清抗GQ1b IgG抗体。我们检测了32例患者的I类抗原（A、B和C）以及30例患者的II类抗原（DR和DQ），但未发现相关性。我们得出结论，在MFS和GBS中，特定血清学定义的HLA类型并非抗GQ1b IgG抗体免疫反应所偏好的类型。
