Hanzaike T, Ito I, Ishikawa T, Ishikawa Y, Kadota K
Rumoi Livestock Hygiene Service Centre, Hokkaido, Japan.
J Comp Pathol. 1995 Apr;112(3):237-42. doi: 10.1016/s0021-9975(05)80077-5.
A 4-year-old Holstein cow developed a large neoplastic mass, which was formed in the deep soft tissue of the neck and removed surgically. The neoplasm was shown to be a smooth muscle tumour by the presence of alpha smooth muscle actin and fine intracytoplasmic filaments with focal densities. This malignant neoplasm showed extensive areas of necrosis and haemorrhage, high cellularity, marked pleomorphism, atypical giant cells and numerous mitoses with occasional abnormal figures.
一头4岁的荷斯坦奶牛颈部深层软组织形成了一个大的肿瘤性肿块，并通过手术切除。通过α平滑肌肌动蛋白的存在以及具有局灶性致密物的细细胞质内细丝，表明该肿瘤为平滑肌瘤。这种恶性肿瘤表现出广泛的坏死和出血区域、高细胞密度、明显的多形性、非典型巨细胞以及大量有偶尔异常形态的有丝分裂。
