Négyessy L, Takács J, Mogensen J, Divac I, Hámori J
1st Department of Anatomy, Semmelweis Medical University, Budapest, Hungary.
J Hirnforsch. 1995;36(3):433-41.
Chronic changes in the thalamic mediodorsal nucleus (MD) after unilateral lesions of the prefrontal cortex were studied with the aid of quantitative light, and electron microscopic immunohistochemistry. Three months after the lesions, although the size of MD ipsilateral to the lesion did not change considerably, the neuronal density was significantly reduced. Conversely, as demonstrated by quantitative electron microscopy, the density of GABA immunostained axon terminals significantly increased in the lesioned side. It is suggested, that as MD does not contain GABA cells, the reactive hyperinnervation of the MD by GABA-containing axons is of extrinsic origin. This finding is also the morphological evidence of the potential of GABA-ergic nerve cells for reactive (induced) axonal sprouting.
借助定量光镜和电子显微镜免疫组织化学技术，研究了前额叶皮质单侧损伤后丘脑背内侧核（MD）的慢性变化。损伤后三个月，尽管损伤同侧MD的大小没有明显变化，但神经元密度显著降低。相反，定量电子显微镜显示，损伤侧GABA免疫染色轴突终末的密度显著增加。由于MD不包含GABA能细胞，提示含GABA轴突对MD的反应性超神经支配源自外部。这一发现也是GABA能神经细胞具有反应性（诱导性）轴突发芽潜力的形态学证据。
