Racca S, Conti G, Pietribiasi F, Stramignoni D, Tampellini M, Valetto M R, Ghezzo F, Di Carlo F
Dipartimento di Scienze Cliniche e Biologiche, Facoltà di Medicina, Orbassano, Torino, Italy.
Int J Biol Markers. 1995 Apr-Jun;10(2):87-93. doi: 10.1177/172460089501000204.
The cytosolic levels of pS2, an estrogen-regulated protein, were measured in 100 cases of primary breast cancer and related to several conventional histological and biochemical prognostic factors. The data were statistically analyzed on the basis of two different cutoff point for pS2: 4 and 11 ng/mg of cytosolic proteins. pS2 positivity (cutoff 11 ng/mg) was shown to be associated with small tumor size (p = 0.05), a higher differentiation grade (p = 0.007) and a smaller number of mitoses (p = 0.004), but not with menopausal status, lymph node involvement, cathepsin D levels, or proliferative activity determined by the monoclonal antibody Ki67. With the cutoff of 4 ng/mg, the statistical significance was confirmed only for the number of mitoses (p = 0.03), which was also the most closely related covariate in multivariate analysis (p = 0.008). As regards steroid receptor status, a significant difference was observed between pS2+ and pS2- cases (Chi-square = 8.9; p = 0.04, cutoff 4 ng/mg). in conclusion, pS2 positivity, being preferentially expressed in hormone-dependent cells and related to other well-known positive markers, may either indicate a good prognosis or predict responsiveness to endocrine treatment.
在100例原发性乳腺癌患者中检测了雌激素调节蛋白pS2的胞质水平，并将其与几种传统的组织学和生化预后因素进行关联分析。基于pS2的两个不同截断点（4和11 ng/mg胞质蛋白）对数据进行统计学分析。结果显示，pS2阳性（截断值为11 ng/mg）与肿瘤体积小（p = 0.05）、高分化程度（p = 0.007）和较少的有丝分裂数（p = 0.004）相关，但与绝经状态、淋巴结受累情况、组织蛋白酶D水平或由单克隆抗体Ki67测定的增殖活性无关。当截断值为4 ng/mg时，仅在有丝分裂数方面证实了统计学意义（p = 0.03），在多变量分析中这也是最密切相关的协变量（p = 0.008）。关于类固醇受体状态，在pS2阳性和阴性病例之间观察到显著差异（卡方 = 8.9；p = 0.04，截断值为4 ng/mg）。总之，pS2阳性在激素依赖性细胞中优先表达且与其他已知的阳性标志物相关，可能预示着良好的预后或预测对内分泌治疗的反应性。
