Pucillo C E, Palmer L D, Hodes R J
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892-1360, USA.
Immunol Res. 1995;14(1):58-68. doi: 10.1007/BF02918497.
Mouse mammary tumor viruses (MMTV) are retroviruses that induce mammary carcinomas. An interesting feature of these viruses is the superantigen (SAg) encoded in an open reading frame within the 3' long terminal repeat. The mechanism by which ingestion of milk-borne virus results in infection of the host mammary tissue remains incompletely understood. However, a working model has been proposed in which the interaction between viral SAg, T-cell receptor and MHC class II I-E facilitates viral replication and hence infectivity. In this review we summarize current studies demonstrating the role of SAg stimulation in susceptibility to MMTV infection.
小鼠乳腺肿瘤病毒（MMTV）是诱发乳腺癌的逆转录病毒。这些病毒的一个有趣特征是在3'长末端重复序列内的一个开放阅读框中编码的超抗原（SAg）。摄入乳汁传播的病毒导致宿主乳腺组织感染的机制仍未完全了解。然而，已经提出了一个工作模型，其中病毒SAg、T细胞受体和MHC II类I-E之间的相互作用促进病毒复制，从而提高感染性。在这篇综述中，我们总结了当前的研究，这些研究证明了SAg刺激在MMTV感染易感性中的作用。
