四种根管封闭剂生物相容性及其对几种组织锌和钙含量影响的实验研究

Experimental study of the biocompatibility of four root canal sealers and their influence on the zinc and calcium content of several tissues.

作者信息

Economides N, Kotsaki-Kovatsi V P, Poulopoulos A, Kolokuris I, Rozos G, Shore R

机构信息

Department of Dental Pathology and Therapeutics, Faculty of Dentistry, Aristotelian University of Thessaloniki, Greece.

出版信息

J Endod. 1995 Mar;21(3):122-7. doi: 10.1016/s0099-2399(06)80436-x.

DOI:10.1016/s0099-2399(06)80436-x

PMID:7561653

Abstract

Four root canal sealers (AH-26, Roth 811, CRCS, and Sealapex) were tested for tissue biocompatibility in rat connective tissue. Each sealer was placed in Teflon tubes and implanted subcutaneously in Wistar-Furth rats. The implants were removed after 7, 14, and 21 days, fixed, and histologically prepared for microscopical evaluation. Brain, liver, kidneys, and uterus were removed from the animals killed at the first experimental period (7 days) and analyzed for zinc and calcium concentration by flame atomic absorption spectrophotometry. In total, 100 specimens were examined. At the seventh day, the most irritant material was seen to be AH-26, but this inflammatory reaction decreased with time. Roth 811 and Sealapex caused moderate-to-severe inflammatory reaction, whereas CRCS caused mild to moderate. CRCS and Roth 811 induced redistribution of zinc, whereas AH-26 induced changes in calcium content in some organs.

摘要

对四种根管封闭剂（AH-26、Roth 811、CRCS和Sealapex）进行了大鼠结缔组织的组织生物相容性测试。每种封闭剂被置于聚四氟乙烯管中，并皮下植入Wistar-Furth大鼠体内。在7天、14天和21天后取出植入物，进行固定，并进行组织学处理以进行显微镜评估。从第一个实验期（7天）处死的动物身上取出脑、肝、肾和子宫，并用火焰原子吸收分光光度法分析锌和钙的浓度。总共检查了100个标本。在第7天，观察到刺激性最强的材料是AH-26，但这种炎症反应随时间而降低。Roth 811和Sealapex引起中度至重度炎症反应，而CRCS引起轻度至中度炎症反应。CRCS和Roth 811诱导锌的重新分布，而AH-26在某些器官中诱导钙含量的变化。