Moyer-Mileur L, Luetkemeier M, Boomer L, Chan G M
Department of Pediatrics, University of Utah, Salt Lake City 84132, USA.
J Pediatr. 1995 Oct;127(4):620-5. doi: 10.1016/s0022-3476(95)70127-3.
A 4-week pilot study was done with 26 preterm infants to evaluate whether a physical activity program would result in greater bone mineralization.
Subjects were matched by birth weight, gender, and gestational age, and randomly assigned to the physical activity program (group EX; n = 13) or to the control group (group C; n = 13). Physical activity consisted of range of motion with passive resistance to all extremities for 5 to 10 minutes daily. Baseline and 4-week values were determined for both bone mineral analyses and serum levels of calcium, phosphate, alkaline phosphatase, parathyroid hormone, and 25-hydroxy-vitamin D.
Despite similar nutrient intake at advised levels for preterm infants, EX infants gained more weight than control subjects (17.8 vs 13.4 gm/kg body weight per day; p = 0.01). A difference in radial bone mass and density change as determined by single-beam photon absorptiometry (+/- 2% error) was found between groups (p = 0.006 by analysis of covariance). Changes in bone width and in bone mineral content and density were enhanced by physical activity. Group EX infants had 12%, 18%, and 34% gains in bone width and in bone mineral density and content, respectively; group C infants had only a 2% gain in bone width and 11% and 14% losses from baseline in bone mineral content and density, respectively, during the 4-week study. Serum biochemical values were similar in the groups except for lower alkaline phosphatase levels in group EX. There was a negative association between bone mineral content and parathyroid hormone values: r = -0.83, p = 0.01.
A physical activity program may increase the effects of adequate nutrition in healthy preterm very low birth weight infants by promoting weight gain and bone mass and by decreasing the risk of osteopenia.
对26名早产儿进行了一项为期4周的初步研究，以评估一项体育活动计划是否会带来更大程度的骨矿化。
根据出生体重、性别和胎龄对受试者进行匹配，并随机分为体育活动组（EX组；n = 13）或对照组（C组；n = 13）。体育活动包括对所有四肢进行被动抵抗的关节活动范围练习，每天5至10分钟。测定了骨矿分析以及血清钙、磷、碱性磷酸酶、甲状旁腺激素和25-羟基维生素D水平的基线值和4周时的值。
尽管两组早产儿的营养摄入量均处于建议水平且相近，但EX组婴儿的体重增长高于对照组（每天17.8克/千克体重 vs 13.4克/千克体重；p = 0.01）。两组之间通过单束光子吸收法（误差±2%）测定的桡骨骨量和密度变化存在差异（协方差分析，p = 0.006）。体育活动增强了骨宽度、骨矿物质含量和密度的变化。EX组婴儿的骨宽度、骨矿物质密度和含量分别增加了12%、18%和34%；在为期4周的研究中，C组婴儿的骨宽度仅增加了2%，骨矿物质含量和密度分别较基线水平下降了11%和14%。除EX组碱性磷酸酶水平较低外，两组的血清生化值相似。骨矿物质含量与甲状旁腺激素值之间存在负相关：r = -0.83，p = 0.01。
一项体育活动计划可能通过促进体重增加和骨量增加以及降低骨质减少的风险，增强充足营养对健康的极低出生体重早产儿的影响。
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