多中心先天性心脏病临床研究：利用研究网络研究重要的未解答问题。
Multicenter Clinical Research in Congenital Heart Disease: Leveraging Research Networks to Investigate Important Unanswered Questions.
机构信息
Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Division of Cardiology, Children's National Hospital, Washington, DC.
出版信息
Neoreviews. 2023 Aug 1;24(8):e504-e510. doi: 10.1542/neo.24-8-e504.
Abstract
Congenital heart disease (CHD) is the most common birth defect in the United States. Neonates with CHD are often cared for by neonatologists in addition to cardiologists. However, there is a paucity of rigorous evidence and limited clinical trials regarding the management of neonates with CHD. In this review, we will describe some of the challenges of research in this field. The Pediatric Heart Network serves as an example of how a research network can effectively overcome barriers to conduct and execute well-designed multicenter studies.
摘要
先天性心脏病（CHD）是美国最常见的出生缺陷。除了心脏病专家外，新生儿 CHD 患者通常还由新生儿科医生进行治疗。然而，对于新生儿 CHD 的管理，目前相关的严格证据和临床试验都很有限。在这篇综述中，我们将描述该领域研究面临的一些挑战。儿科心脏网络（Pediatric Heart Network）就是一个研究网络如何有效克服障碍、开展和执行精心设计的多中心研究的范例。
相似文献
1
Multicenter Clinical Research in Congenital Heart Disease: Leveraging Research Networks to Investigate Important Unanswered Questions.多中心先天性心脏病临床研究：利用研究网络研究重要的未解答问题。
Neoreviews. 2023 Aug 1;24(8):e504-e510. doi: 10.1542/neo.24-8-e504.
2
Rethinking Congenital Heart Disease in Preterm Neonates.重新思考早产儿的先天性心脏病。
Neoreviews. 2022 Jun 1;23(6):e373-e387. doi: 10.1542/neo.23-6-e373.
3
The pediatric heart network: meeting the challenges to multicenter studies in pediatric heart disease.儿科心脏网络：应对儿科心脏病多中心研究的挑战
Curr Opin Pediatr. 2015 Oct;27(5):548-54. doi: 10.1097/MOP.0000000000000260.
4
The Pediatric Heart Network: a primer for the conduct of multicenter studies in children with congenital and acquired heart disease.儿科心脏网络：先天性和后天性心脏病患儿多中心研究实施指南
Pediatr Cardiol. 2006 Mar-Apr;27(2):191-8. doi: 10.1007/s00246-005-1151-9.
5
Accuracy of cardiac auscultation in asymptomatic neonates with heart murmurs: comparison between pediatric trainees and neonatologists.无症状心脏杂音新生儿心脏听诊的准确性：儿科实习生与新生儿科医生的比较
Pediatr Cardiol. 2011 Apr;32(4):473-7. doi: 10.1007/s00246-011-9905-z. Epub 2011 Feb 17.
6
The Role of the Neonatologist in Fetuses Diagnosed with Congenital Heart Disease.新生儿科医生在诊断先天性心脏病胎儿中的作用。
Neoreviews. 2023 Sep 1;24(9):e553-e568. doi: 10.1542/neo.24-9-e553.
7
Comprehensive comparative outcomes in children with congenital heart disease: The rationale for the Congenital Catheterization Research Collaborative.先天性心脏病患儿的综合比较结果：先天性导管介入研究协作组的基本原理。
Congenit Heart Dis. 2019 May;14(3):341-349. doi: 10.1111/chd.12737.
8
Emerging Research Directions in Adult Congenital Heart Disease: A Report From an NHLBI/ACHA Working Group.成人先天性心脏病的新兴研究方向：美国国立心肺血液研究所/美国先天性心脏病协会工作组的报告
J Am Coll Cardiol. 2016 Apr 26;67(16):1956-64. doi: 10.1016/j.jacc.2016.01.062.
9
[The competence network for congenital heart defects. Networking instead of isolated efforts for optimized research and care].[先天性心脏病能力网络。通过网络协作而非孤立努力实现优化研究与护理]
Med Klin (Munich). 2006 Sep 15;101(9):753-8. doi: 10.1007/s00063-006-1104-4.
10
Prematurity and Congenital Heart Disease: A Contemporary Review.早产与先天性心脏病：当代综述
Neoreviews. 2022 Jul 1;23(7):e472-e485. doi: 10.1542/neo.23-7-e472.
本文引用的文献
1
Pediatric and Congenital Cardiovascular Disease Research Challenges and Opportunities: JACC Review Topic of the Week.儿科与先天性心血管病研究的挑战与机遇：《美国心脏病学会杂志》每周综述专题。
J Am Coll Cardiol. 2022 Dec 6;80(23):2239-2250. doi: 10.1016/j.jacc.2022.09.032.
2
The Relationship of Family Factors to Psychosocial Outcomes in Children with Hypoplastic Left Heart Syndrome at 6 Years of Age.家庭因素与左心发育不全综合征患儿6岁时心理社会结局的关系。
J Pediatr. 2023 Apr;255:50-57.e2. doi: 10.1016/j.jpeds.2022.10.016. Epub 2022 Oct 17.
3
Addressing Social Determinants of Health and Mitigating Health Disparities Across the Lifespan in Congenital Heart Disease: A Scientific Statement From the American Heart Association.解决先天性心脏病患者全生命周期的健康社会决定因素问题和减少健康差异：美国心脏协会的科学声明。
J Am Heart Assoc. 2022 Apr 19;11(8):e025358. doi: 10.1161/JAHA.122.025358. Epub 2022 Apr 7.
4
Promoting inclusion in clinical trials-a rapid review of the literature and recommendations for action.促进临床试验中的包容性——文献快速回顾及行动建议。
Trials. 2021 Dec 4;22(1):880. doi: 10.1186/s13063-021-05849-7.
5
Unique Challenges of Randomised Controlled Trials in Pediatric Cardiology.儿科心脏病学中随机对照试验的独特挑战
Can J Cardiol. 2021 Sep;37(9):1394-1403. doi: 10.1016/j.cjca.2021.06.013. Epub 2021 Jun 27.
6
Family Function, Quality of Life, and Well-Being in Parents of Infants With Hypoplastic Left Heart Syndrome.先天性左心发育不全综合征患儿父母的家庭功能、生活质量和幸福感。
J Fam Nurs. 2021 Aug;27(3):222-234. doi: 10.1177/1074840720987309. Epub 2021 Feb 4.
7
Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.心脏病与中风统计-2021 更新：美国心脏协会报告。
Circulation. 2021 Feb 23;143(8):e254-e743. doi: 10.1161/CIR.0000000000000950. Epub 2021 Jan 27.
8
US Mortality Attributable to Congenital Heart Disease Across the Lifespan From 1999 Through 2017 Exposes Persistent Racial/Ethnic Disparities.美国 1999 年至 2017 年期间与先天性心脏病相关的全生命周期死亡率揭示了持续存在的种族/民族差异。
Circulation. 2020 Sep 22;142(12):1132-1147. doi: 10.1161/CIRCULATIONAHA.120.046822. Epub 2020 Aug 3.
9
Corrigendum to ``Increasing Diversity in Clinical Trials: Overcoming Critical Barriers''. [Current Problems in Cardiology, Volume 44, Issue 5 (2019) 148-172].
Curr Probl Cardiol. 2021 Mar;46(3):100647. doi: 10.1016/j.cpcardiol.2020.100647. Epub 2020 Jul 25.
10
Updated Strategies for Pulse Oximetry Screening for Critical Congenital Heart Disease.更新的脉搏血氧饱和度筛查严重先天性心脏病的策略。
Pediatrics. 2020 Jul;146(1). doi: 10.1542/peds.2019-1650. Epub 2020 Jun 4.
Zotero 插件