Occurrence of Actinobacillus actinomycetemcomitans and anti-leukotoxin antibodies in some members of an extended family affected by Papillon-Lefèvre syndrome.

Eighteen (18) members of an extended family in which numerous individuals have Papillon-Lefèvre syndrome (PLS) were examined. In all, 6 affected members and 12 non-affected members were included. All patients underwent a clinical examination which, in the dentate persons, included plaque index, bleeding on probing, probing depth, and periodontal attachment loss and a set of full mouth periapical x-rays. Subgingival bacterial samples were also collected from 2 teeth in the dentate patients for cultures and identification of Actinobacillus actinomycetemcomitans. Serum samples were collected from all participants and assayed for antileukotoxin antibodies. The results indicate that there is a high prevalence of leukotoxic strains of A. actinomycetemcomitans in persons suffering from PLS, as well as in unaffected family members. The ubiquitous presence of A. actinomycetemcomitans in the family units suggests a close association between A. actinomycetemcomitans and the periodontal disease associated with the syndrome; it also suggests that A. actinomycetemcomitans by itself is not sufficient for the expression of periodontal disease and that other factors, some of which must be genetic, are necessary for lesion development.