Salcido R, Fisher S B, Donofrio J C, Bieschke M, Knapp C, Liang R, LeGrand E K, Carney J M
Chandler Medical Center, University of Kentucky, Lexington 40536, USA.
J Rehabil Res Dev. 1995 May;32(2):149-61.
Pressure ulcers continue to be a major health care problem. This paper describes an animal model and surface pressure delivery system for the production of experimentally derived pressure ulcers. A method for inducing dermal pressure lesions on the fuzzy rat was developed using a computer-controlled displacement column which produced a constant tissue interface pressure. The pressure column consists of a force transducer located between two 0.5-in (1.27-cm) diameter metal cylinders. The desired cutaneous pressure is maintained by a computer-controlled miniature stepper motor which displaces the column with the aid of interactive software. The force transducer signal is converted from analog to digital form, amplified, and recorded. Blood perfusion is monitored using a laser Doppler flowmeter (located in the tip of the column) during the application of pressure. The application of 145 mmHg pressure for 5 consecutive 6-hr sessions resulted in a greater than 90% incidence of pressure ulcers. The implications of our model and contributions of earlier animal models are discussed. This model provides a tightly controlled and measured environment making possible the scientific study of ulcer development and the evaluation of potential preventative or curative compounds.
压疮仍然是一个重大的医疗保健问题。本文描述了一种用于产生实验性压疮的动物模型和表面压力传递系统。利用计算机控制的位移柱开发了一种在模糊大鼠上诱导皮肤压力损伤的方法，该位移柱可产生恒定的组织界面压力。压力柱由位于两个直径为0.5英寸（1.27厘米）的金属圆柱体之间的力传感器组成。所需的皮肤压力由计算机控制的微型步进电机维持，该电机借助交互式软件移动压力柱。力传感器信号从模拟形式转换为数字形式，进行放大并记录。在施加压力期间，使用激光多普勒流量计（位于压力柱尖端）监测血液灌注。连续5个6小时的疗程施加145 mmHg的压力导致压疮发生率超过90%。讨论了我们模型的意义以及早期动物模型的贡献。该模型提供了一个严格控制和测量的环境，使得对溃疡发展的科学研究以及对潜在预防或治疗化合物的评估成为可能。
