武装部队医务人员的乙型肝炎感染免疫接种。

Immunisation of armed service medical personnel against hepatitis B infection.

作者信息

Cumberland N S, Sloss J M, Green A D, Masterton R G, Sims M M

机构信息

Department of Pathology, Queen Elizabeth Military Hospital, London.

出版信息

J R Army Med Corps. 1995 Jun;141(2):78-81.

PMID:7562742

Abstract

Clinical and laboratory staff of the Army and RAF medical services at risk of acquiring infection with hepatitis B were immunised against the virus with a recombinant vaccine. Vaccine was administered in Service hospitals and medical centres located throughout the world. After a primary course of vaccine, 73% of personnel developed anti-HBs titres > or = 100 IU/L to hepatitis B surface antigen and were considered protected; 11% were non-responders (anti-HBs < 10 IU/l). A significantly higher proportion of females than males, and vaccinees under 40 years of age, produced a good response. Among those achieving a good response, antibody titres were higher in the younger age group and in females. After a fourth (booster) dose of vaccine, 87.2% of the poor responders and 37% non-responders, developed anti-HBs titres > or = 100 IU/L.

摘要

陆军和皇家空军医疗服务部门中面临感染乙型肝炎风险的临床及实验室工作人员，接种了重组疫苗以预防该病毒。疫苗在遍布全球的军队医院和医疗中心进行接种。在完成疫苗的基础免疫疗程后，73%的人员产生了针对乙型肝炎表面抗原的抗-HBs滴度≥100 IU/L，被视为受到了保护；11%的人员无应答（抗-HBs＜10 IU/l）。女性和40岁以下的接种者产生良好应答的比例显著高于男性。在产生良好应答的人群中，较年轻年龄组和女性的抗体滴度更高。在接种第四剂（加强）疫苗后，87.2%的低应答者和37%的无应答者产生了抗-HBs滴度≥100 IU/L。