Airio A, Pukkala E, Isomäki H
Department of Internal Medicine, University Hospital of Turku, Finland.
J Rheumatol. 1995 Jul;22(7):1300-3.
To study the relationship of polymositis (PM) and dermatomyositis (DM) and cancer in Finland.
The medical records of 175 patients with PM and 71 with DM diagnosed between 1969 and 1985 were reviewed. The patients were followed until death or until December 30, 1990 through the files of Statistics Finland and the Finnish Cancer Registry.
Thirty-four cases of cancer were found [standardized incidence ratio (SIR) 2.1, 95% confidence interval 1.4-2.9]. In the PM group the SIR was 1.0 (95% CI 0.5-1.8), and in the DM group 6.5 (95% CI 3.9-10). The relative risk of cancer among DM cases was very high (SIR 26, 12-48) in the first year after DM diagnosis.
DM is associated with cancer, but not PM. The risk is high among patients with DM older than 49. Cytotoxic drugs given to DM patients did not increase the risk of malignancies. DM and certain cancers seem to share etiological factors.
研究芬兰多发性肌炎（PM）、皮肌炎（DM）与癌症之间的关系。
回顾了1969年至1985年间确诊的175例PM患者和71例DM患者的病历。通过芬兰统计局和芬兰癌症登记处的档案对患者进行随访，直至死亡或1990年12月30日。
发现34例癌症病例[标准化发病比（SIR）为2.1，95%置信区间为1.4 - 2.9]。在PM组中，SIR为1.0（95%CI 0.5 - 1.8），在DM组中为6.5（95%CI 3.9 - 10）。DM病例诊断后的第一年，患癌相对风险非常高（SIR 26，12 - 48）。
DM与癌症相关，但PM与癌症无关。49岁以上的DM患者患癌风险较高。给予DM患者的细胞毒性药物并未增加患恶性肿瘤的风险。DM和某些癌症似乎有共同的病因。
