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非洛地平-美托洛尔缓释片:其特性与临床开发。

A felodipine-metoprolol extended-release tablet: its properties and clinical development.

作者信息

Dahlöf B, Andersson O K

机构信息

Department of Medicine, Ostra Hospital, Gothenburg, Sweden.

出版信息

J Hum Hypertens. 1995 Jul;9 Suppl 2:S43-7.

PMID:7562899
Abstract

The current failure of antihypertensive therapy to control BP in many hypertensive patients highlights the need for new treatment strategies. Ideally, these new strategies should provide reliable, effective 24 h BP control in all types of patients with a convenient, well-tolerated regimen. Logimax, an extended-release tablet containing felodipine and metoprolol, has been developed, which provides more effective control of BP in a wider range of patients than either component as monotherapy, without compromising tolerability. This combination increases the likelihood of achieving target BP and is therefore likely to provide further reductions in cardiovascular risk.

摘要

目前,许多高血压患者的降压治疗未能有效控制血压,这凸显了新治疗策略的必要性。理想情况下,这些新策略应能以方便且耐受性良好的方案,为所有类型的患者提供可靠、有效的24小时血压控制。Logimax是一种含有非洛地平和美托洛尔的缓释片,与单一成分的单药治疗相比,它能在更广泛的患者中更有效地控制血压,且不影响耐受性。这种联合用药增加了实现目标血压的可能性,因此可能进一步降低心血管风险。

相似文献

1
A felodipine-metoprolol extended-release tablet: its properties and clinical development.非洛地平-美托洛尔缓释片:其特性与临床开发。
J Hum Hypertens. 1995 Jul;9 Suppl 2:S43-7.
2
Improving the therapeutic balance between efficacy and tolerability in antihypertensive drugs--the rationale and benefits of combining felodipine and metoprolol.
J Hum Hypertens. 1995 Jul;9 Suppl 2:S37-42.
3
A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT).美托洛尔琥珀酸盐缓释片与非洛地平缓释片联合治疗高血压的析因研究——美托洛尔琥珀酸盐-非洛地平抗高血压联合试验(M-FACT)结果
Am J Hypertens. 2006 Apr;19(4):388-95. doi: 10.1016/j.amjhyper.2005.10.007.
4
Antihypertensive efficacy and tolerability of a new once-daily felodipine-metoprolol combination compared with each component alone. The Swedish/UK Study Group.一种新型每日一次非洛地平-美托洛尔复方制剂与单一组分相比的降压疗效及耐受性。瑞典/英国研究小组。
Blood Press Suppl. 1993;1:22-9.
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Design and pharmacokinetics of Logimax, a new extended-release combination tablet of felodipine and metoprolol.洛吉马克斯(Logimax)的设计与药代动力学,一种新型的非洛地平与美托洛尔缓释复方片剂。
Blood Press Suppl. 1993;1:10-5.
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The long-term antihypertensive efficacy and safety of a new felodipine-metoprolol combination tablet. The Swedish/UK and German Study Groups.
Blood Press Suppl. 1993;1:46-50.
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Comparison of a felodipine-metoprolol combination tablet vs each component alone as antihypertensive therapy. The German Multicentre Study Group.非洛地平 - 美托洛尔复方片剂与各单一成分作为抗高血压疗法的比较。德国多中心研究小组。
Blood Press Suppl. 1993;1:30-6.
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Felodipine-metoprolol combination tablet: maintained health-related quality of life in the presence of substantial blood pressure reduction.非洛地平-美托洛尔复方片剂:在显著降低血压的情况下维持与健康相关的生活质量。
Am J Hypertens. 2005 Oct;18(10):1313-9. doi: 10.1016/j.amjhyper.2005.04.017.
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Improved antihypertensive efficacy of the felodipine-metoprolol extended-release tablet compared with each drug alone.非洛地平-美托洛尔缓释片相较于单独使用每种药物,其降压疗效有所提高。
Blood Press Suppl. 1993;1:37-45.
10
[Prospects of use of the combined preparation logimax in patients with essential hypertension].
Ter Arkh. 2002;74(1):61-3.

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Comparison of candesartan and felodipine alone and combined in the treatment of hypertension: a single-center, double-blind, randomized, crossover trial.坎地沙坦与非洛地平单用及联用治疗高血压的比较:一项单中心、双盲、随机、交叉试验。
Curr Ther Res Clin Exp. 2003 Jul;64(7):380-8. doi: 10.1016/S0011-393X(03)00128-0.