一种带有3-(4-苯甲酰基苯基)丙酰基探针的新型紫杉醇光亲和类似物，用于表征微管蛋白和P-糖蛋白上的药物结合位点。 - Suppr

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A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.

作者信息

Ojima I, Duclos O, Dormán G, Simonot B, Prestwich G D, Rao S, Lerro K A, Horwitz S B

机构信息

Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.

出版信息

J Med Chem. 1995 Sep 29;38(20):3891-4. doi: 10.1021/jm00020a001.

DOI:10.1021/jm00020a001

PMID:7562921

Abstract

摘要

相似文献

A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.

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引用本文的文献

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A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.

作者信息

Ojima I, Duclos O, Dormán G, Simonot B, Prestwich G D, Rao S, Lerro K A, Horwitz S B

机构信息

Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.

出版信息

J Med Chem. 1995 Sep 29;38(20):3891-4. doi: 10.1021/jm00020a001.

DOI:10.1021/jm00020a001

PMID:7562921

Abstract

摘要

相似文献

A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.

J Med Chem. 1995 Sep 29;38(20):3891-4. doi: 10.1021/jm00020a001.

Synthesis of a photoaffinity taxol analogue and its use in labeling tubulin.

J Med Chem. 1994 Sep 2;37(18):2976-80. doi: 10.1021/jm00044a019.

[3H](azidophenyl)ureido taxoid photolabels peptide amino acids 281-304 of alpha-tubulin.

Biochemistry. 1997 Apr 1;36(13):3820-5. doi: 10.1021/bi961602r.

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.

J Biol Chem. 1994 Feb 4;269(5):3132-4.

Chemistry and chemical biology of taxane anticancer agents.

Chem Rec. 2001;1(3):195-211. doi: 10.1002/tcr.1008.

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin.

J Biol Chem. 1995 Sep 1;270(35):20235-8. doi: 10.1074/jbc.270.35.20235.

Photoaffinity labeling of P-glycoprotein in multidrug-resistant cells.

Cancer Invest. 1993;11(1):46-56. doi: 10.3109/07357909309020260.

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5312-6. doi: 10.1073/pnas.051309398. Epub 2001 Apr 17.

Woodchuck p-glycoprotein found in virus-induced hepatocellular carcinomas binds anticancer drugs.

Cancer Lett. 1996 Dec 20;110(1-2):177-80. doi: 10.1016/s0304-3835(96)04488-6.

Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.

J Nat Prod. 2018 Mar 23;81(3):600-606. doi: 10.1021/acs.jnatprod.7b01047. Epub 2018 Mar 8.

引用本文的文献

Structural insight into the stabilization of microtubules by taxanes.

Elife. 2023 Mar 6;12:e84791. doi: 10.7554/eLife.84791.

Utilization of Photoaffinity Labeling to Investigate Binding of Microtubule Stabilizing Agents to P-Glycoprotein and β-Tubulin.

J Nat Prod. 2022 Mar 25;85(3):720-728. doi: 10.1021/acs.jnatprod.2c00106. Epub 2022 Mar 3.

Prodrug Strategies for Paclitaxel.

Int J Mol Sci. 2016 May 23;17(5):796. doi: 10.3390/ijms17050796.

Molecular analysis of the multidrug transporter, P-glycoprotein.

Cytotechnology. 1998 Sep;27(1-3):31-60. doi: 10.1023/A:1008023629269.

Design, synthesis, and biological evaluation of new-generation taxoids.

J Med Chem. 2008 Jun 12;51(11):3203-21. doi: 10.1021/jm800086e. Epub 2008 May 9.