Jegliński W, Koczyk D, Zaremba M, Oderfeld-Nowak B
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warszawa, Poland.
J Neurosci Res. 1995 Jun 15;41(3):394-402. doi: 10.1002/jnr.490410312.
Unilateral damage to the lateral fimbria led to a bilateral gliosis in the septum and hippocampus. The gliosis was manifested by an increase in GFAP staining, accompanied by an increased number of glial fibrillary acidic protein (GFAP)(+) cells and GFAP content; the latter however was not visible in the contralateral septum. In general, the contralateral reaction appeared weaker than the ipsilateral one. The pattern of contralateral increase in GFAP-immunoreactivity (IR) matched almost exactly that observed on the ipsilateral side in the hippocampus (the most evident increase was seen in the oriens and pyramidal layers of cornu Ammonis 3 and in polymorphic area of gyrus dentatus). In the septum the bilateral increase in GFAP-IR was mainly visible in the dorsolateral quadrant of the structure; however in the ipsilateral side it spread over the whole half of the structure. The astrocytic responses in the septum and hippocampus were not equivalent: they differed mainly with regard to the increase of GFAP(+) cells (over 300% of control in the anterior part of the septum and only about 120% in the dorsal hippocampus). The differences between the percentage increases of other gliotic indices: GFAP-IR and GFAP content. Various possibilities that may account for the occurrence of contralateral gliosis are discussed, the most plausible being the contribution of interhemispheric and intraseptal links and the action of some diffusible agents. We suggest that bilateral gliosis may have an impact on compensatory postlesion processes, possibly by providing trophic support to impaired neurons.
外侧穹窿单侧损伤导致隔区和海马双侧胶质增生。胶质增生表现为胶质纤维酸性蛋白（GFAP）染色增加，伴有胶质纤维酸性蛋白（GFAP）阳性细胞数量和GFAP含量增加；然而，对侧隔区未观察到GFAP含量增加。一般来说，对侧反应比同侧反应弱。对侧GFAP免疫反应性（IR）增加的模式与同侧海马几乎完全匹配（最明显的增加见于海马3区的海马伞和锥体细胞层以及齿状回多形层）。在隔区，GFAP-IR的双侧增加主要见于该结构的背外侧象限；然而，在同侧，它分布于该结构的整个半侧。隔区和海马的星形胶质细胞反应并不相同：它们主要在GFAP阳性细胞增加方面存在差异（隔区前部超过对照组的300%，而背侧海马仅约120%）。其他胶质增生指标增加百分比之间的差异：GFAP-IR和GFAP含量。讨论了可能导致对侧胶质增生的各种可能性，最合理的是半球间和隔区内连接的作用以及一些可扩散因子的作用。我们认为双侧胶质增生可能对损伤后的代偿过程有影响，可能是通过为受损神经元提供营养支持。
