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Combination finasteride and flutamide in advanced carcinoma of the prostate: effective therapy with minimal side effects.

作者信息

Fleshner N E, Trachtenberg J

机构信息

Division of Urology, University of Toronto, Canada.

出版信息

J Urol. 1995 Nov;154(5):1642-5; discussion 1645-6.

PMID:7563310
Abstract

PURPOSE

The efficacy of the combination of finasteride and flutamide in select patients with advanced prostatic cancer is determined.

MATERIALS AND METHODS

A total of 22 sexually active patients with stages C and D1 carcinoma of the prostate was treated with finasteride plus flutamide. Mean followup was 22 months.

RESULTS

Initial mean prostate specific antigen level was 42.9 ng./ml. At 3 and 6 months, the mean prostate specific antigen level was 3.6 ng./ml. and 2.9 ng./ml., respectively. The results appear durable at 24 months. Side effects were minimal, with 86% of the men maintaining sexual function.

CONCLUSIONS

Finasteride plus flutamide should be considered in sexually active patients with minimal volume advanced prostate cancer.

摘要

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